ABSTRACT
<p><b>OBJECTIVE</b>To observe the protective effects of resveratrol (RES) on the heart function of the rats with adriamycin-induced heart failure.</p><p><b>METHOD</b>Thirty adult male SD rats were randomly divided into 5 groups: normal control (NC) group, adriamycin (ADR) group, RESL + ADR group, RES(H) + ADR group and RES group. RES of 30, 120, 120 mg x kg(-1) x d(-1) was given intraperitoneally (ip) once a day for 3 days in RES(L) + ADR group, RES(H) + ADR group and RES group respectively. The other two groups were given the same amount of normal saline the same way. On the 4h day,ADR of 10 mg x kg(-1) was given intraperitoneally once to induce myocardium injury model. After twenty-four hours, the pathological and biochemical changes of the myocardium were examined.</p><p><b>RESULT</b>As compared with NC group, the MDA, NO and NOS of the ADR group were significantly higher (P < 0.05), and the SOD of the ADR group were markedly lower (P < 0.05). As compared with ADR group, the indexes in RES(L) + ADR group, RES(H) + ADR group were exactly opposing, and took on dose dependance (P < 0.05). Light microscopic morphometry of the heart samples of the rats in ADR + RES(L, H) groups revealed typical diminishing of damage.</p><p><b>CONCLUSION</b>RES can relieve the toxic effects of ADR on myocardium, and the cardioprotective effects may be correlated with its antioxidant activity and downregulation of NO.</p>
Subject(s)
Animals , Male , Rats , Doxorubicin , Heart , Heart Failure , Pathology , Malondialdehyde , Blood , Myocardium , Pathology , Nitric Oxide , Blood , Nitric Oxide Synthase , Blood , Random Allocation , Rats, Sprague-Dawley , Stilbenes , Pharmacology , Superoxide Dismutase , BloodABSTRACT
<p><b>OBJECTIVE</b>To study the effects of resvaratrol derivatives on spontaneous HR and CF of isolated guinea pig atrium.</p><p><b>METHOD</b>The dose-effect curve of resvaratrol was observed. The possible mechanism of potassium channels responsible for changes of CF and HR after administering with resvaratrol was measured.</p><p><b>RESULT</b>Resvaratrol reduced the spontaneous HR and weakened the CF in a dose-dependent manner ranging from 10(-6) to 3 x 10(-4) mol x L(-1) (P < 0.05). As compared with Res group, the effects were partly blocked by Gli (P < 0.05) and TEA (P < 0.01), but not blocked by 4-AP, BaCl2, Atropine.</p><p><b>CONCLUSION</b>Resvaratrol can induce negative chronotropic action and negative (inotropic action. The mechanism(s) may relate to the opening of K(ATP) and Kc(Ca).</p>